Friday, November 29, 2019

Plato Essays (675 words) - Socratic Dialogues, Philosophy Of Love

Plato Plato How do we know if love is a god or just a little baby we call cupid that flies around during Valentines? Plato's Symposium is a piece of work that is dedicated to Eros the god of love. I choose to disuse Agathon's and Socrates's speeches because they are both similar in subject, but opposite in opinion. Socrates's ideas on Eros, identify him as a spirit in-between beauty and good. He is also in-between love and knowledge. In Socrates's form of Eros, Eros is not seen as a god who is contrary to Agathon's speech. I defend Socrates because his ideas are thought out and argued in Symposium. Socortes's speech starts out with a wise women named Diotima. She tells him how Eros came to be, she states that Eros was conceived on Aphdites birthday ?that's why he is also by nature a lover of beauty, because Aphrodite herself is especially beautiful? (203C). Socrates added to this by saying since knowledge is beautiful and he is a lover of beauty he also is a philospilla. Eros then desire's and seeks knowledge just as all human beings do. Finally since he seeks similar wants and needs as humans do, he is not a god but in-between the heavens and the earth as Socrates puts it he is a ?great spirit? (202E). Agathon view of Eros is completely different, he focus on his dominance as a god. He states that Eros is the youngest god, he points this out by saying there was Gavaldon 2 war with the gods but it ceased when Eros was present. Agathon than says that he has a hold on the gods because they themselves are in love. Since he is so supreme he is the creator of everything fair and good on earth. If Eros is both young and beautiful, he also has a hold on other gods from the effects of love. Agathon concludes Eros is the creator of everything good and fair. Thus Agathon states that Eros is the King of the Gods. Socrates and Agathon speeches come up with the extreme conclusion that the two give an in-depth look on the intentions and the roles Eros plays in our world. While Agthon says that Eros is beauty, Socrates goes the opposite way stating, Eros is only the lover of beauty, therefore he is not beautiful, because if you have someone who is beautiful he doesn't seek beauty. Socrates uses knowledge and refers it to humans and gives the statement that Eros requires knowledge as well as beauty just as mortals do. They try to prove that Eros is in-between immortality and moral, though Agothon boasts that Eros in fact is the supreme ruler of the gods, presuming god is in fact immortal. These two men Agathon and Socrates' in the dialogues of Symposium have strong arguments, yet I find that I agree with Socrates rather than Agathon's happy go lucky world of bliss. Socrates premises are straightforward. He gives you surrounding information-disproving Agathon as he goes in the dialogue. As Socrates explains one idea as he leads into the other and intertwines them to a Gavaldon 3 conclusion. Yet, Agathon seems set on a easy explanation of Eros. As he goes along his speech he gives reasons on why Eros is the god but only to keep referring on the fact that Eros is beautiful and young. I defend Socrates' because he gave a better description as well as step by step of Agathon speech in Symposium. Agathon's speech to me seemed he was caught up it enchantism rather than giving an argument and concluding it as Socrates did in his speech. Socrates speech was well spoken because he had all the elements for a good speech. First he gave the impression that another person was responsible for the words that he spoke. Then he told us the origin of Eros, and then proceeded to fill in the rest that Agathon has left out in his speech of the god of love. Philosophy Essays

Monday, November 25, 2019

Favorite Quotes From Faulkners As I Lay Dying

Favorite Quotes From Faulkners As I Lay Dying As I Lay Dying is the fictional chronicle of Addie Bundrens death. The family undertakes a journey to bury her body. The novel is narrated with the shifting viewpoints of 15 characters- made all the more vivid with Faulkners use of the vernacular and stream-of-consciousness style. Here are a few quotes from As I Lay Dying. Riches is nothing in the face of the Lord, for He can see into the heart.The quilt is drawn up to her chin, hot as it is, with only her two hands and her face outside. She is propped on the pillow, with her head raised so she can see out the window, and we can hear him every time he takes up the adze or the saw. If we were deaf we could almost watch her face and hear him, see him. Her face is wasted away so that the bones draw just under the skin in white lines. Her eyes are like two candles when you watch them gutter down into the sockets of iron candlesticks. But the eternal and the everlasting salvation and grace is not upon her.I know her. Wagon or no wagon, she wouldnt wait. Then shed be upset, and I wouldnt upset her for the living world. With that family burying-ground in Jefferson and them of her blood waiting for her there, shell be impatient. I promised my word me and the boys would get her there quick as mules could walk it, so she could rest quiet.I have heard men cuss th eir luck, and right, for they were sinful men. But I do not say its a curse on me, because I have done no wrong to be cussed by. I am not religious, I reckon. But peace is my heart: I know it is. I have done things but neither better nor worse than them that pretend otherlike, and I know that Old Marster will care for me as for ere a sparrow that falls. But is seems hard that a man in his need could be so flouted by a road. I knew that nobody but a luckless man could ever need a doctor in the face of a cyclone.Its because Im alone. If I could just feel it, it would be different, because I would not be alone. But if I were not alone, everybody would know it. And he could do so much for me, and then I would not be alone. Then I could be all right alone.I reckon if theres ere a man or woman anywhere that He could turn it all over to and go away with His mind at rest, it would be Cora. And I reckon she would make a few changes, no matter how He was running it. And I reckon they would be for mans good. Leastways, we would have to like them. Leastways, we might as well go on and make like we did.The wagon moves; the mules ears begin to bob. Behind us, above the house, motionless in tall and soaring circles, they diminish and disappear.We go on, with a motion so soporific, so dreamlike as to be uninferant of progress, as though time and not space were decreasing between us and it.I heard that my mother is dead . I wish I had time to let her die. I wish I had time to wish I had. It is because the wild and outraged earth too soon too soon too soon. She cried hard, maybe because she had to cry so quiet; maybe because she felt the same way about tears she did about deceit, hating herself for doing it, hating him because she had to. And then I knew that I knew. I knew that as plain on that day as I knew about Dewey Dell on that day.It is as though the space between us were time: an irrevocable quality. It is as though time, no longer running straight before us in a diminishing line, now runs parallel between us like a looping string, the distance being the doubling accretion of the thread an not the interval between.Because it is not us that can judge our sins or know what is sin in the Lords eyes. She has had a hard life, but so does every woman. But youd think from the way she talked that she knew more about sin and salvation than the Lord God Himself, than them who have strove and labored with the sin in this human world.While I waited for him in the woods, waiting for him before he saw me, I would think of him as dressed in si n. I would think of him as thinking of me as dressed also in sin, he the more beautiful since the garment which he had exchanged for sin was sanctified. I would think of the sin as garments which we would remove in order to shape and coerce the terrible blood to the forlorn echo o the dead word high in the air. Then I would lay with Anse again - I did not lie to him: I just refused, just as I refused my breast to Cash and Darl after their time was uphearing the dark land talking the voiceless speech. I give that money. I thought that if I could do without eating, my sons could do without riding. God knows I did.It had been dead eight days, Albert said. They came from some place in Yoknapatawpha County, trying to get to Jefferson with it. It must have been like a piece of rotten cheese coming into an anti-hill, in that ramshackle wagon that Albert said folks were scared would fall all to pieces before they could get it out of town, with that home-made box and another fellow with a broken leg lying on a quilt on top of it, and the father and a little boy sitting on the seat and the marshal trying to make them get out of town.Jewel came back. He was walking. Jewel hasnt got a horse anymore. Jewel is my brother. Cash is my brother. Cash has a broken leg. We fixed Cashs leg so it doesnt hurt. Cash is my brother. Jewel is my brother too, but he hasnt got a broken leg.When I went to find where they stay at night, I saw something that Dewey Dell says I mustnt never tell nobody. Life was created in the valleys. It blew up into the hills on the old terrors, the old lusts, the old despairs. Thats why you must walk up the hills so you can ride down.Sometimes I aint so sho whos got ere a right to say when a man is crazy and when he aint. Sometimes I think it aint none of us pure crazy and aint none of us pure sane until the balance of us talks him that-a-way. Its like it aint so much what a fellow does, but its the way the majority of folks is looking at him when he does it.She looked pretty good. One of them black eyed ones that look like shed as soon put a knife in you as not if you two-timed her. She looked pretty good.Yes yes yes yes yes yes yes.Its Cash and Jewel and Vardaman and Dewey Dell, pa says, kind of hangdog and proud too, with his teeth and all, even if he wouldnt look at us. Meet Mrs Bundren, he says.

Thursday, November 21, 2019

Internet forum should be more strictly controlled for the entries Essay

Internet forum should be more strictly controlled for the entries because internet forum can encourage harmful and misleading news - Essay Example Therefore, there is need to control the internet forums by imposing strict regulations on its usage. However, controlling the internet forum may attract criticism as people may feel that this is one of the laws limiting the public freedom, which the constitution grants. In reality, Internet forum should be more strictly controlled for the entries because internet forum can encourage harmful and misleading news. Internet forums refer to any forms of internet channels that are responsible for providing information to the access of the public. They may include any official internet news sites or even social networks that provide information to the public. The issue of controlling the internet forums is a concept that has for long drawn attention from many scholars. Controlling internet forums refers to the imposition of strict measures against its abuse in providing information. In the era of internet technology, many internet forums have emerged, making it entirely a big challenge to control the information that is relayed through these channels. While there is evidence that these forums are informative, it is clear that they can be used to relay raw information that may be untruthful, hurtful or even misleading. Misleading information refers to any material facts that may influence negatively the reaction of the people or even bring about a controversy. However, several policies have been p ut into place as a control mechanism for internet use. For instance, â€Å"regulations would force Internet companies to apply for a license if theyre running a microblog or forum† (Shalvey 1). Due to the sensitivity of information, it is crucial that every information that is relayed through these channels be reliable and truthful. Misleading information may have far reaching effects to the receiver or even to the world. In many occasion, the news items report different information, putting people in

Wednesday, November 20, 2019

Media appraisal Essay Example | Topics and Well Written Essays - 2500 words

Media appraisal - Essay Example By combing these methods the author has an original approach to her research and this makes it very interesting to criticise. The paper shows how the role of popular music in society has been studied traditionally and challenges some classical methodologies while also proposing new ones. It is the combination of these points which makes this article good to study in terms of research methodology analysis. The study is of popular music in the lives of young people. It positions itself with cultural and social studies. Its aim is to approach the study of the role of popular music in a slightly different way from other researchers on this subject. Initially the author states that few studies work directly with the people who use and consumer music. The study therefore aims to change this by asking people directly what their experience of music is, instead of making theories that do not in interact with reality. The author emphasises the need to concentrate on the real experiences which people have, or say they have, in relation to music. Related to this is the aim to explore what the author refers to as the ‘everydayness’ of music. Rather than focusing on the cultural significance of music through issues such as identity construction, the paper aims to explore the possibility that these issues of music consumption are in fact less important than the more mundane and routine uses of music in everyday life, as a background noise whose meanings are irrelevant. She focuses on the ‘fallacy of meaningfulness’, arguing that music doesn’t necessarily have to be significant or used to define a particular group or consumed by a particular ethnic group or social class. The methodology used by the author involves the use of unstructured informal discussions with three groups of GCSE sociology students, around fifteen years old. Three groups of four to five students were involved in one discussion, all on the same day. There were fewer boys than girls in all

Monday, November 18, 2019

CSR for business managers, stakeholders and society Research Paper

CSR for business managers, stakeholders and society - Research Paper Example Therefore it is the duty of the companies to work in accordance with the interests of the community and environment. However, only few companies are strictly observing CSR in practice, even though most of the companies agree with CSR in principle. This paper analyses the reputation of Coca Cola in terms of corporate social responsibility. Description of the company Operating in more than 200 countries worldwide, the American company Coca cola is one among the largest soft drink manufacturers in the world at present. â€Å"In May, 1886, Coca Cola was invented by Doctor John Pemberton a pharmacist from Atlanta, Georgia. Today, products of the Coca Cola Company are consumed at the rate of more than one billion drinks per day† (Bellis). Even though PepsiCo is causing some serious challenges to Coca Cola in some part of the world, Coca Cola is able to maintain its superiority in most of the regions in the world. Issue Identification According to Jeff Seabright, The Coca-Cola Compan y's vice president of environment and water resources, â€Å"sustainability begins with the simple act of paying attention. You can't manage what you can't measure"(Making Sustainability the Real Thing). In other words, Coca Cola is well aware of the importance of concepts such as corporate social responsibility and sustainable development. However, the accusations against Coca Cola with respect to the violation of social responsibility are growing across the world. ... People from Kerala (India’s southernmost state) have recently conducted an agitation against the underwater exploitation by Coca Cola. Villagers near Plachimada, Kerala faced severe drinking water shortage because of Coca Cola’s uncontrolled underwater exploitation. Coca Cola forced to close down their plant at Plachimada because of the public agitation against them (EMJ). Significance of the Issue Drinking water shortage is one of the major problems facing by people all over the world. Because of injudicious farming activities and heavy industrialization, majority of the water resources such as rivers and streams were polluted in most parts of the world. As a result of that current generation is relying heavily on underwater resources for their drinking needs. Coca Cola like soft drink manufacturers is exploiting these resources and the people near the soft drink bottling plants are struggling to get enough drinking water from the nature. Stakeholder identification Som e of the major stakeholders of Coca Cola Company are; ordinary people, Coca Cola employees, shareholders in Coca Cola, government and local bodies. On one side, Coca Cola is trying to make profit and safeguard the interests of the company management and the shareholders. On the other side, ordinary people lose their drinking water resources and the government and local bodies struggle to take proper actions. It should be noted that as part of free trade agreements, it is the duty of the government of India to prepare enough facilities to Coca Cola like companies. Moreover, Indian government is currently trying to attract foreign direct investment at any cost to stimulate economic growth. The investments by Coca Cola would definitely help

Saturday, November 16, 2019

PhD Proposal Writing | Contributing to knowledge

PhD Proposal Writing | Contributing to knowledge To define an original contribution to knowledge in the context of PhD studies is complicated. In one sense, it can be seen as something which someone else has not done before and requires a large amount of innovation and commitment from the researcher. Gall et al. (1996:47) noted that the imagination and insight that goes into defining the research problem usually determines the ultimate value of a research study more than any other factor. This definition however may be construed as too broad and can be complimented by the reasoning given by Grix (2001) who says that a substantial contribution to knowledge means you must have produced original research on a given topic and embedded it firmly in the received wisdom of a particular field To pin point a definition for an original contribution to knowledge is difficult. However, Madsen (1983:25) offers the following as a possible start: Original means the potential to do at least one of the following: uncover new facts or principles, suggest relationships that were previously unrecognized, challenge existing truths or assumptions, afford new insights into little-understood phenomena, or suggest new interpretations of known facts that can alter mans perception of the world around him. It is widely agreed within academic fields that a contribution to knowledge may be achieved through a number of ways. Frances (1976) pinpoints eight ways in which originality can be achieved. However, Estelle and Derek (2010) only concur with six of these points which are as follows: Setting down a major piece of new information in writing for the first time; Continuing a previously original piece of work; Carrying out original work designed by the supervisor; Providing a single original technique, observation, or result in an otherwise unoriginal but competent piece of research; Having many original ideas, methods, and interpretations all performed by others under the direction of the postgraduate; Showing originality in testing somebody elses ideas. Fundamentally, an original contribution to knowledge can be seen as an ambiguous statement or process as it can be interpreted by different people in a variety of ways. Dunleavy (2003) expresses concerns regarding overstating the originality of the research and emphasises the need to balance innovation against the subject context. He goes on to suggest that the best way to proceed in research is to think of the contribution as value-added. He clarifies this by saying, Focusing on your own value added means keeping a critical eye on the extent to which you have transformed or enhanced or differentiated the starting materials of your analysis. He also goes on to say that, It also means retaining strong relational patterns of argument in which you appropriately acknowledge the extent to which you draw on the existing literature. The importance of reading literature in the chosen area of research cannot be over emphasised. Without this fundamental grounding of knowledge, a serious student cannot begin to propose an original contribution to knowledge. Without having a working understanding of the literature in their field, it is made more difficult for students to refine a researchable topic and then subsequently contribute original knowledge. Knowledge of the field is critical and includes knowing what has already been done, what the current hot topics are and projected issues and trends. Ultimately, researchers need to understand what has already been accomplished before attempting to add their own contribution to the field. Consideration must be given to any personal relevancy the proposed topic holds for the student and what area of their study would represent the biggest contributions of their work. When researching the literature, it is important to keep in mind such questions as: Is there any controversy or inconsistencies in the research or data? Does a deficiency appear in the literature on a particular topic? From a historical perspective, how has the field arrived at its present level of understanding the phenomenon that is being pursued? Broader topics are probably more helpful because the broader the topic is, the more numerous are the kinds of research questions that can be asked (Crowl, 1996:20). During the processes of PhD studies and writings, students can only make initial proposals as to what they perceive as original contributions. However, as time progresses and more literature is explored, these initial proposals will change if it is discovered that there has already been some research of a similar nature, and therefore if the initial proposals do not adapt, new ones are creased in their place. Put succinctly, it means not just passively following the authors train of thought but more importantly, it means anticipating where the authors line of argument leads, considering alternative extensions and constructing your own framework that covers these possibilities. Some of the best ideas are born this way. (Krathwohl, 1994:29) Relating this contextually, my PhD research is in the area of Dyslexia in the public and private sectors and its affect on policy making and implementation. The topic chosen is still broad in terms of the area I may investigate. However the focus of my research is narrowing as more literature is read and evaluated. After discussions with my Supervisor who is a specialist in Diversity and Equalities, my research will also attempt to grasp what the perceptions are of dyslexia in the public and private sectors and will see how these mind sets influence the decisions of various departments and relationships within the business and public sectors. An area I am also keen to investigate is the education of staff and the general public through schooling and awareness programmes and other media. From the literature that I have reviewed to date, I know that there has been little research undertaken with regards to dyslexia policies in the educational sector. What has been researched quite extensively is the educational policies which relate primarily to primary and secondary education. There has been little discussion relating to dyslexia during college and university participation. Therefore, I know that any theories I have surrounding higher education and any research I wish to initiate will most likely result in an original contribution to knowledge. There has been next to no academic writing about dyslexia policies in the private sector which gives me, as a researcher, a good opportunity to offer some original contribution to knowledge to this field. What has been written in this field focuses primarily on what is required to comply with national legislation and European law. Drake (1999) summarises policies and laws simply by stating, à ¢Ã¢â€š ¬Ã‚ ¦ prevailing norms and values reflect the interests of the majority and may subordinate those of the minority. I agree with this statement but wish to find out just how much this holds true in the context of public and private sectors. What has generally been written about dyslexia in the public and private sector areas has been more from a social sciences view stemming from definitions of dyslexia as opposed to stemming from the more business minded and practical view which focuses more on a persons ability to do jobs and the influence this has on company and or educational policies. Therefore, in an area which has been under explored and scrutinised, the research I propose to carry out will be original as it will produce new theories as to why dyslexia is barely acknowledge in these areas, along with new insights into how the current policy systems are produced and operated and possibly where new systems and legislation would be beneficial. There will be an obvious flourish of new ideas and arguments which accompany any original contribution, as well as an opportunity to apply any existing ideas in general literature to the new area of study. This is important in my field, as dyslexia in itself, as a form of disability can be controversial and any new ideas and hypothesis made will be cause for debate and allow past discussions to be revisited. This is also important in the development of original contributions as this will allow any theories created to adapt and grow. Apart from my own literature search, by speaking with other academics in my specific field, I can gain access to a whole new level of expertise and academic knowledge. This will give me the opportunity to test their knowledge of my chosen area of diversity and tap into their resources. Additionally, they will also be able to aide in identifying if my chosen topic has been previously mentioned in any literature that they have read. Academics will not be the only resource I will be able to tap throughout my investigations, as I will also have access to many other resources such as peers, advisors, supervisors, university staff and government offices. Other resources will follow as my research develops. Despite the obvious views of original contributions to knowledge, other questions still remain. One example of this is when a student continues a previously original piece of work, is it truly original? The answer would be in the affirmative in the following cases; for example, if the direct result were to produce new theoretical interpretation to an already given state; to extend, qualify, elaborate existing work; or even create a new research design and/or methodology for research. The latter example would clearly have an impact on any work that I was to produce. This form of original contribution to knowledge is popular when covering an already highly researched area. This allows the researcher to explore areas which have already been explored but have the possibilities to be interpreted in different ways. Also, when a theoretical model is brought from one discipline and applied to another discipline, it can create many interesting results. In the context of my research, there has been one author who has looked generally on policies surrounding disabilities, all be it more substantially from a political (government) viewpoint. However he does not go into detail on dyslexia specifically as this is not the focus of his research when making the general link to companies. What he has passingly touched on in the case of dyslexia would be something I would like to investigate further in my own research. The specific case is the reactions of the managers in companies towards disabled employees. In my research however, I would more specifically want to look at dyslexics. Another area of interest in my chosen topic has been that indirectly covered by wildlife experts. There have been many links made regarding the relationship that exists between mankind and animals, and I believe there are still many more links to be made. For example, if one animal is perceived to be different, then it is often excluded from the group or pack. This link can be made with people. When someone is perceived as different, they can often be persecuted directly or indirectly. This may involve a lowering of self worth or esteem and lead to social exclusion. There can be many assumptions as to why this is, and there are already existing theories with regards to animal behaviour. Therefore I would like to use these theories in a different field/context which again substantiates an original contribution to knowledge. Other areas of originality can be highlighted with fresh data which can lead directly into critical appraisal of previous work. Care needs to be taken not to re-create previous works, or have something which is too closely associated with a previous research specimen. A whole new stance needs to be taken. When a student, using fresh data, undertakes further research of a topic previously covered ten years earlier, there is a strong chance that the results now would differ. This could tentatively lead on to a new theory being uncovered as to the reason behind the change and would thus be considered as another original contribution to knowledge. If during my research I find that an area I wish to explore has already been covered, and yet I find myself disagreeing with the outcomes from the findings I have made, I would gather more data, if time permitted, which would allow me to critically appraise that piece of work with new findings. For example, if twenty years ago research formulated a theory covering managers reactions to disabled people in the banking industry, I would have no hesitation in contemplating further research in this area considering the drastic change in law, disability policies and banking practices over the intervening years. However, if all the work presented is relatively recent, yet I find myself disagreeing with the analysis, my original contribution could be a new analysis and new outcome from the existing data. This in turn could lead onto a fresh theoretical interpretation and even prompt a new analysis and new results derived from the old data. No matter how a research student deduces whether or not they have made an original contribution to knowledge, what matters is that there is a support structure in place to help and guide them. Mauch and Birch (1989) constructed a series of questions to guide researchers when trying to determine the relative strength of research topics, which in my opinion goes hand in hand with original knowledge contribution. Some of the questions highlighted by Mauch and Birch are as follows: 1. Is there current interest in this topic in your field? 2. Is there a gap in knowledge that work on this topic could fill? 3. Is it possible to focus on a small enough segment of this particular topic to make it manageable? 4. Can you envision a way to study the topic that will allow conclusions to be drawn with substantial objectivity? 5. Is the data collection (i.e., test, questionnaire, interviews, etc.) acceptable to your advisor and in your department? 6. Is there a body of literature relevant to the topic? 7. Is a search of the topic manageable? 8. Are there large problems to be surmounted in working in this topic? Can you handle them? Do you want to handle them? 9. Are the needed data easily accessible? Will you have control of the data? Placing the above in context, I can determine whether or not my own research ticks the boxes of this checklist and therefore can ascertain, in another way, whether or not my own work can be considered an original contribution to knowledge. In the instance of the first question, this is irrelevant to an original contribution. However, it does help make the process of PhD writing easier if there is interest and it is therefore a good starting point for a structure. The answer is yes. Interest in disabilities, although diminishing into the background of public awareness over recent years, is still there in the academic world. The second question is vital to original contributions to knowledge as previously discussed. Again, the answer is yes. The area of research I have chosen has been under researched and is therefore a treasure trove waiting to be explored further. Questions 3 to 5 along with 7 and 9 are more focused in and around managing the actual research and data collection. Although not immediately linked to the original contribution to knowledge, they do play a factor in deciding whether or not an area should be further investigated. Question 6 focuses on literature which we have established as being paramount to ascertaining an original contribution to knowledge. In my context, there is literature surrounding dyslexia but more from a sociological perspective. So far in my literature investigations I have not uncovered anything alluding to the subject area I wish to investigate. The final relevant question, number 8, can challenge a researcher when confronted with an original contribution to knowledge in a controversial area. Is it something a first time researcher wants to investigate or is it best left until another opportunity arises in the future? Not only is this an issue, this question also raises further questions about other issues. For example, ethical issues. When thinking about an original contribution to knowledge, a researcher must also take other factors into consideration. Ultimately, the topics surrounding What is an original contribution to knowledge are still quite broad and all encompassing, but with guidance from supervisors and the numerous books available, researchers, including myself, should not have any serious difficulty finding an original contribution to knowledge. A succinct summary for the process of thinking about an original contribution to knowledge is nicely stated by Rojewski in Farmer, E. I., Rojewski, J. W. (2001), Its been almost two weeks now. You spend what seems like, every waking moment thinking about it. And yet, still nothing. In a cruel twist of fate, it seems that the more time you spend thinking about it the more elusive the answer becomes. Why cant someone just give it to you already and then you can be done with it!

Wednesday, November 13, 2019

Essay example --

Alzheimer’s disease (AD) is a degenerative brain disease that involves dysfunctions and loss of nerve cells in central nervous system, was discovered by a German physician, Dr. Alois Alzheimer in 1907. As it is accounted for 50 to 75% of all cases of dementia, it is the most common form of dementia (Blennow et al., 2006) and it is known as a progressive neuropsychiatric disorder which involves memory loss, mood swing and loss of intellectual and social skills (Lee et al., 2010) and sufferer will progress through seven-stages of Alzheimer but with different rate (Reisberg et al., 2003). Prevalence of dementia increases exponentially with age from 60 to 85 years old or older, which is Senile plaques, neurofibrillary tangles, loss of synapses and degeneration of basal forebrain cholinergic neurons are the neuropathological hallmarks of this disease (Shen et al., 2005). It is a neurodegenerative disorder with unknown cause (Blennow et al., 2006). There are some hypotheses of pathogenesis of Alzheimer’... ... are able to interfere some metabolic pathways of choline metabolism. Hence, they have broad range on neurologic effects. From the experiment, monosubstituted 2-aminoethanols give the least inhibitory activity. There will be an increase in inhibitory activity when the degree of substitution and molecular size of the nitrogenous head of the molecule increase, due to the increase in the chance for van der Waals’ interaction with the protein surface, results in increased enzyme inhibition (Hartung, 1968). This complied with the principle of inhibitors with tertiary amino compounds act on PAS site. Enzyme inhibition occurs by steric blockade (Rosenberry et al., 1999) or allosteric activation (Auletta et al., 2010) will give low number of empty enzymes for further hydrolysis. Therefore, dialkylaminoflavonols shold be futher investigated in the discovery of better drugs.